Enter The Substance, a mysterious liquid that promises to solve all her problems.

Instead, it just introduces a new one: Margaret Qualley’s Sue.

Substance Plot Explained

The Substancestarts by introducing audiences to the concept of its titular creation.

Demi Moore in The Substance

An egg yolk is given a dose of The Substance and very quickly splits into two.

Things get so bad that Elizabeth is fired from her once-highly-rated aerobics show.

Elizabeth is old news.

Margaret Qualley in The Substance movie

To make matters even worse (somehow), a car accident lands her in the hospital.

It’s here where the move starts to pick up.

But what exactly is she switching off from?

Demi Moore in The Substance movie

Well, that answer is given in a horrific fashion after she injects herself with the activator.

A completely naked, freshly created human being tears itself out of Elizabeth’s older body.

This is the brand new you to which The Substance program referred.

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The program insists that the two beings are one and not separate.

Yet, each has their own memories and experiences and does not share a conscience.

Elizabeth, thankfully, isn’t dead.

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She is the perfect replacement for Harvey to put on their new show.

In contrast, Elizabeth’s life is not so perfect.

This angers Sue, who becomes more impulsive and reckless with how she handles the switches.

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It gets so bad that, at one point, she stays out longer than her allotted seven days.

She tries to call the person who gave her The Substance, but he is unable to help her.

At one point, Elizabeth even runs across the doctor who first offered her the Substance.

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She is now unrecognizable, having aged what seems like multiple decades, leaving nearly all her hair behind.

But it’s worse than thatshe isn’t just old.

In a panic, she calls the number for The Substance and demands to stop the program.

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They give Elizabeth termination fluid that would end Sue in a safe manner.

Elizabeth drags Sue out into her living room, where she starts to inject the fluid.

She gets halfway before looking again at Sue’s big billboard outside the window.

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She sees the leftover termination fluid that Elizabeth was trying to use and snaps.

Sue, enraged, goes to attack her former self.

In a bloody, violent fashion, Sue beats Elizabeth to death.

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Instead, a monstrous, terrifying version of Sue and Elizabeth is born.

This new creation is truly hideous and disturbing.

It looks like something from theDead Spacegames or the end creature inEvil Dead Rise.

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At this point, the movie leaves behind all subtlety and dives deep into satire.

Despite pleading,“It’s me,“the audience attacks the monster.

It even gets decapitated, which results in the dead growing right back in its place.

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It is not gone, though.

A mutated version of Elizabeth’s face remains as it attempts to find refuge.

Fittingly, it gets as far as Elizabeth Sparkle’s Hollywood Star on the Walk of Fame before dying.

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The Substanceis now playing in theaters worldwide.

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