Amazon Prime’s latest animated comedy is headlined by Stephanie Hsu and Keke Palmer.

Together, they tackle various wild and unpredictable intergalactic medical cases.

She also recently appeared in the underrated comedy featureJoy Ride.

Sam Smith, Kieran Culkin, Second Best Hospital Wallpaper

Her anxiety is also a main thread throughout the entire first season.

Keke Palmer earned acclaim for her performance in Jordan Peele’s filmNopein 2022.

Before this, he appeared in notable works such asScott Pilgrim vs. the Worldand season 2 ofFargo.

Stephanie Hsu next to her character Dr. Sleech.

His psychic and mental abilities help him treat his patients from across the galaxy.

Natasha Lyonne, who portrays Nurse Tup, has garnered acclaim for her roles in streaming television.

She delivered stellar performances inNetflix’sOrange is the New BlackandRussian Doll, before appearing inPeacock’sPoker Facedirected byRian Johnson.

Keke Palmer alongside her character Dr. Klak.

Lyonne not only stars inThe Second Best Hospital in the Galaxybut also is one of the executive producers.

She recently appeared in the filmAmerican Fictionalongside Jeffrey Wright.

He has also appeared in comedy films likeBrosandFire Island, as well as the acclaimed sitcomNora From Queens.

Kieran Culkin next to his character Dr. Plowp.

Additionally, Ellis starred as Reuben “Payback” Fitch inTop Gun: Maverick.

Rory Culkin

Joining his other brothers in a brief appearance is Rory Culkin.

Christian Culkin

The next Culkin bro joiningThe Second Best Hospital in the Galaxyis Christian.

Maya Rudolph next to her character Dr. Vlam.

He hasn’t had an active acting career but he did appear in 1994’sMy Summer Storyas Randy Parker.

Shane, the oldest brother, previously played Wally Webb inOur Townon Broadway.

The Second Best Hospital in the GalaxySeason 1 is now streaming on Prime Video.

Natasha Lyonne alongside her character Nurse Tup.

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Tracee Ellis Ross next to her animated character.

Bowen Yang next to his animated character.

Abbi Jacobson next to her animated character.

Andrew Dismukes alongside his animated character.

Lennon Parham alongside her animated character.

John Waters next to his animated character.

Macaulay Culkin in a recent project.

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