Long-running medical drama Grey’s Anatomy is back with some fresh and familiar faces.
Grey’s Anatomyfollows the employees' lives at Grey Sloan Memorial Hospital in Seattle.
Throughout that time, plenty of characters and cast members have come and gone on theGrey’s Anatomyset.
In Season 19 of the series, Pompeo scaled back her appearances as Meredith.
However, she continued to guest star in the series and provide narration for the episodes.
She also refused an offer from Catherine that would have kept her job.
Miranda was once the Chief of Surgery at Grey Sloane and the winner of the prestigious Catherine Fox award.
Outside ofGrey’s Anatomy, Wilson has also been seen inGeneral HospitalandStation 19.
Pickens Jr. is also known for his roles onThe X-FilesandRoseanne.
Most recently, McKidd appeared as one of the cast members in Blake Lively’sIt Ends With Us.
Caterina Scorsone portrays Amelia inGrey’s Anatomyand its spin-offs,Private PracticeandStation 19.
Raver is known for her work on24, Designated Survivor,andRay Donovan.
In the finale, Jo opted not to reveal her pregnancy to Link.
Chris Carmack portrays Link.
The actor also has credits inNashvilleandThe OC.
Simone Griffith has often struggled to balance her demanding work and personal life.
Alexis Floyd, star ofInventing AnnaandThe Bold punch in, plays Simone.
To prevent nepotism accusations, he avoids associating with them at all costs.
But he could stay after his love interest, Simone, rallied the interns to support him.
ActorJason George jumped to sister seriesStation 19to continue portraying the character.
In Season 20, Ben was last seen called to the frontlines of the wildfires in Seattle.
In the Season 20 finale, she is also implicated in an emergency surgery where the patient dies.
However, she is expected to appear to finish her character’s arc.
Nick is Meredith’s longtime on-again-off-again love interest.
After departing the show in Season 17, Jackson moved to Boston with his wife, April.
Debbie Allen portrays Catherine inGrey’s Anatomyand is also an executive producer and director on the series.
Beltran is an attending pediatric surgeon at Grey Sloane Memorial Hospital.
In Season 20, she helped Levi achieve his peds fellowship recommendation and began a romance with Winston.
Morales has been seen inDead to Me, The Morning Show, andNo Hard Feelings.
Michael Thomas Grant - James
A newcomer toGrey’s Anatomyis Michael Thomas Grant as James.
According toTV Line, James is the hospital’s new openly gay chaplain.
The actor is known mainly for his role as Leif inZoey’s Extraordinary Playlist.
New episodes ofGrey’s AnatomySeason 21 air on Thursdays on ABC at 10 p.m.
ET and stream the next day on Hulu.
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